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Second primary tumors and immune phenomena after fludarabine or 2-chloro-2'-deoxyadenosine treatment
E Van Den Neste1, A Delannoy, W Feremans
1Department of Hematology, Cliniques universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium. vandenneste@sang.ucl.ac.be
Leukemia & Lymphoma
|June 28, 2001
Abstract:
The purine nucleoside analogs fludarabine and 2-chloro-2'-deoxyadenosine display substantial activity in the treatment of various chronic lymphoproliferative disorders. Their major toxicities are primarily immunosuppression and myelosuppression. The profound influence of these drugs on the immune system has raised questions as to the emergence of secondary neoplasms or auto-immune disorders after their use. Based on a literature review and on personal observations, this article reviews the potential clinical importance of these concerns.