Related Experiment Video

Updated: Sep 14, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

Potential roles of antisense technology in cancer chemotherapy

S T Crooke1

  • 1Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA.

Oncogene
|June 28, 2001
PubMed

Insights

Antisense technology shows promise for cancer chemotherapy, offering a valuable tool for gene functionalization and target validation. Emerging data suggest antisense drugs are safe and effective in preclinical and clinical cancer studies.

Area of Science:

  • Biotechnology
  • Molecular Biology
  • Oncology

Background:

  • Antisense technology utilizes nucleic acid molecules to modulate gene expression.
  • It has emerged as a significant tool in molecular biology and drug development.
  • Its application in cancer treatment is a rapidly evolving field.

Purpose of the Study:

  • To review the advancements in antisense technology for cancer chemotherapy.
  • To discuss the current landscape of anticancer antisense drugs in development.
  • To explore the future potential of antisense technology in oncology.

Main Methods:

  • Review of existing literature on antisense technology and its applications in cancer.
  • Analysis of preclinical and clinical data for antisense-based cancer therapies.
  • Discussion of gene functionalization and target validation using antisense approaches.

Main Results:

  • Antisense technology is a valuable tool for gene functionalization and target validation in cancer research.
  • Substantial evidence indicates the safety of antisense drugs.
  • Growing data demonstrate activity in animal cancer models and suggest efficacy in human cancer patients.

Conclusions:

  • Antisense technology holds significant potential for the future of cancer chemotherapy.
  • Continued research and development are crucial for realizing its full therapeutic benefits.
  • Antisense drugs represent a promising class of therapeutics for various cancers.

More Related Videos

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Related Concept Videos

RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference01:23

RNA Interference

RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the ATP-dependent...
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...