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Therapeutic implications of inflammation in atherosclerotic cardiovascular disease
C H Selzman1, S A Miller, A H Harken
1Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA. craig.selzman@uchsc.edu
Insights
Atherosclerosis is an inflammatory disease. Understanding vascular injury mechanisms can lead to targeted therapies to halt or reverse atherosclerosis progression.
Area of Science:
- Cardiovascular Medicine
- Pathology
- Immunology
Background:
- Atherosclerosis is a complex disease characterized by diverse pathological lesions and clinical outcomes.
- Emerging evidence suggests that arteriosclerosis, a form of atherosclerosis, is fundamentally an inflammatory condition.
Purpose of the Study:
- To review the inflammatory mechanisms underlying atherosclerosis.
- To explore how understanding vascular injury responses can inform therapeutic strategies.
Main Methods:
- Literature review of studies on vascular injury response pathways.
- Analysis of inflammatory processes in the development and progression of atherosclerosis.
Main Results:
- The review consolidates evidence supporting the inflammatory paradigm of atherosclerosis.
- Identified key mechanisms in the response to vascular injury are crucial for disease pathogenesis.
Conclusions:
- Viewing atherosclerosis as an inflammatory disease provides a framework for developing novel treatments.
- Targeting specific inflammatory pathways involved in vascular injury holds promise for halting or regressing atherosclerosis.
Abstract:
Atherosclerosis represents a spectrum of pathologic lesions with diverse clinical sequelae. In this review, we build upon the paradigm that arteriosclerosis represents an inflammatory disease. By examining mechanisms involved in the response to vascular injury, we can more effectively implement targeted therapy aimed at halting or regressing arteriosclerosis.