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MMR vaccine in HIV-infected children -- potential hazards?

P Goon1, B Cohen, L Jin

  • 1Imperial College School of Medicine at St. Mary's, Norfolk Place, London W2 1PG, UK. p.goon@ic.ac.uk

Vaccine
|June 28, 2001
PubMed

Insights

The measles component of the MMR vaccine can cause disease in HIV-infected children. This case highlights the risk of vaccine-strain measles in immunocompromised populations.

Area of Science:

  • Immunology
  • Virology
  • Pediatrics

Background:

  • Measles, Mumps, and Rubella (MMR) vaccine is routinely given to HIV-infected children for prophylaxis against wild-type measles.
  • Live attenuated viral vaccines carry a potential risk of disease in immunocompromised individuals.

Observation:

  • A case of measles caused by the vaccine strain was documented in an HIV-infected child in the UK.
  • The clinical and immunological aspects of this vaccine-strain measles infection were analyzed.

Findings:

  • The study confirms that the live attenuated measles component of the MMR vaccine can cause measles in HIV-infected children.
  • This finding underscores the potential pathogenicity of live vaccines in immunocompromised hosts.

Implications:

  • The findings necessitate careful consideration of MMR vaccination strategies for HIV-infected children.
  • New guidelines for MMR vaccination in HIV-infected children, adopted in the USA, are discussed in light of this case.
  • This case highlights the importance of monitoring vaccine-preventable diseases in immunocompromised populations.

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