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Risk factors for neonatal seizures: a population-based study, Harris County, Texas, 1992-1994.

R M Saliba1, F J Annegers, D K Waller

  • 1The University of Texas School of Public Health, Houston, TX 77030, USA. rsaliba@mdanderson.org

American Journal of Epidemiology
|June 28, 2001
PubMed
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Birth weight is a key risk factor for neonatal seizures, especially for preterm infants (<1,500g). Other factors include delivery method and hospital type, highlighting the need for further perinatal complication research.

Area of Science:

  • Neonatalogy
  • Pediatric Neurology
  • Epidemiology

Background:

  • Neonatal seizures are a critical concern in newborn care.
  • Identifying risk factors is essential for prevention and management.

Purpose of the Study:

  • To evaluate various risk factors associated with clinical neonatal seizures.
  • To analyze the relationship between infant characteristics and seizure occurrence.

Main Methods:

  • Retrospective cohort study of 116,048 infants born in Harris County, Texas (1992-1994).
  • Data collected from birth certificates.
  • Univariate and multivariate logistic regression analyses were performed.

Main Results:

  • For preterm infants, low birth weight (<1,500g) was the strongest risk factor (RR=9.1).

Related Experiment Videos

  • Other significant factors included hospital type and male gender for preterm infants.
  • For term infants, cesarean section, small birth weight for gestational age, hospital type, and maternal age were significant risk factors.

    • Conclusions:

    • Birth weight is a significant predictor of neonatal seizures.
    • Delivery method and hospital of birth also play a role.
    • Further research into perinatal complications is warranted.