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Increasing multidrug resistance in Helicobacter pylori strains isolated from children and adults in Mexico

J Torres1, M Camorlinga-Ponce, G Pérez-Pérez

  • 1Unidad de Investigación Médica en Enfermedades Infecciosas, Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Mexico City, Mexico. jtorres1@axtel.net

Journal of Clinical Microbiology
|June 28, 2001
PubMed

Insights

Helicobacter pylori antimicrobial resistance is high in Mexican patients, with significant increases in multidrug resistance observed between 1995 and 1997. Metronidazole and clarithromycin resistance were particularly prevalent.

Area of Science:

  • Medical Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Helicobacter pylori is a major cause of gastrointestinal diseases.
  • Antimicrobial therapy is crucial for H. pylori eradication.
  • Monitoring antimicrobial susceptibility patterns is essential for effective treatment.

Purpose of the Study:

  • To determine the antimicrobial susceptibility profiles of H. pylori strains from Mexican patients.
  • To assess trends in antimicrobial resistance over a two-year period.

Main Methods:

  • Phenotypic antimicrobial susceptibility testing was performed on 195 H. pylori isolates.
  • Isolates were obtained from patients in Mexico.
  • Data analysis included resistance rates and trends over time.

Main Results:

  • High resistance rates were observed: 80% to metronidazole, 24% to clarithromycin, and 18% showed transient amoxicillin resistance.
  • A significant increase in resistance to two or more antimicrobials was noted from 1995 to 1997.

Conclusions:

  • H. pylori strains in Mexico exhibit substantial resistance to key antimicrobials.
  • The rising trend in multidrug resistance necessitates urgent attention for treatment strategies.

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