Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Individual differences in response to regular physical activity.

C Bouchard1, T Rankinen

  • 1Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA. bouchac@pbrc.edu

Medicine and Science in Sports and Exercise
|June 28, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A polymorphism of the 5'-flanking region of the glucocorticoid receptor gene locus is associated with basal cortisol secretion in men.

Metabolism: clinical and experimental·2000
Same author

7-year stability of blood pressure in the Canadian population.

Preventive medicine·2000
Same author

Hypertension in obesity and the leptin receptor gene locus.

The Journal of clinical endocrinology and metabolism·2000
Same author

Polymorphisms of the beta2-adrenergic receptor gene (ADRB2) in relation to cardiovascular risk factors in men.

Journal of internal medicine·2000
Same author

Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men.

Thrombosis research·2000
Same author

A genetic study of sex hormone--binding globulin measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study.

Metabolism: clinical and experimental·2000
Same journal

Cardiorespiratory Fitness and Age-Related Decline in Kidney Function among Individuals with Preserved Kidney Health: The Aging Kidney Study.

Medicine and science in sports and exercise·2026
Same journal

Objectively Measured Cardiorespiratory Fitness as a Potential Biomarker for Alzheimer's Disease Risk in Older Adults: Evidence from the Generation 100 Study.

Medicine and science in sports and exercise·2026
Same journal

The Effects of Eight-Week Traditional Aerobic Exercise and Exergaming on Dual-Task Performance and Prefrontal Cortex Activation in Older Adults.

Medicine and science in sports and exercise·2026
Same journal

The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Metabolism and Function.

Medicine and science in sports and exercise·2026
Same journal

Female Athletes Through the Lifespan: Clinical Considerations and a Call for Comprehensive Sports Medicine Healthcare.

Medicine and science in sports and exercise·2026
Same journal

Artificial Intelligence in Exercise Science and Sports Medicine.

Medicine and science in sports and exercise·2026
See all related articles

Individual responses to exercise training vary significantly. While age, sex, and race have minimal impact, pre-training fitness levels and familial factors strongly influence how individuals adapt to physical activity.

Area of Science:

  • Exercise Physiology
  • Human Adaptation
  • Genetics of Exercise Response

Background:

  • Individual variability in response to exercise training is a recognized phenomenon.
  • Understanding factors contributing to this heterogeneity is crucial for personalized exercise prescriptions.

Purpose of the Study:

  • To review interindividual variation in responsiveness to regular exercise training.
  • To define the contributions of age, sex, race, and pretraining phenotype level to this variability.

Main Methods:

  • Literature review of studies on interindividual variation in response to controlled exercise training.
  • Analysis of HERITAGE Family Study data on VO(2max), HDL-C, HR, and SBP training responses.
  • Inclusion of age, sex, race, and initial phenotype values as covariates.

Related Experiment Videos

Main Results:

  • Significant heterogeneity observed in VO(2max) and other phenotypes in response to exercise training.
  • Age, sex, and race showed minimal impact on training response variability.
  • Pretraining phenotype level significantly influenced responses for traits like submaximal HR and BP, but less so for VO(2max) and HDL-C.
  • Familial factors demonstrated significant aggregation for training response phenotypes.

Conclusions:

  • Considerable heterogeneity exists in human responsiveness to regular physical activity.
  • Age, sex, and ethnic origin are not primary determinants of exercise training response.
  • Pretraining phenotype level is a significant determinant for some traits.
  • Familial factors play a substantial role in the variability of training responses.