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Related Experiment Videos

Intestinal calcium binding protein in uremia.

W A Gleason, N L Grimme, L V Avioli

    Calcified Tissue International
    |July 3, 1979
    PubMed
    Summary

    Intestinal calcium binding protein (CaBP) levels are normal in uremic patients, indicating that calcium malabsorption in uremia is not due to a deficiency of this protein. This finding suggests vitamin D responsiveness is not limited by intestinal CaBP.

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    Area of Science:

    • Nephrology
    • Endocrinology
    • Gastroenterology

    Background:

    • Uremic patients often exhibit calcium malabsorption, a condition potentially linked to vitamin D metabolism.
    • Intestinal calcium binding protein (CaBP) plays a crucial role in calcium absorption and vitamin D responsiveness.

    Purpose of the Study:

    • To evaluate intestinal biopsies as indicators of end-organ responsiveness to vitamin D in uremic patients.
    • To investigate the activity and content of CaBP in the intestines of uremic patients compared to healthy controls.

    Main Methods:

    • Measurement of calcium binding activity and CaBP content in intestinal biopsies from 12 uremic patients and 12 controls.
    • Analysis of biopsy site variations and correlation with serum parathormone and 25-hydroxycholecalciferol (25-OHD) levels.

    Main Results:

    • Calcium binding activity and CaBP content varied by biopsy site, with highest levels in the duodenal bulb.
    • No significant differences in CaBP activity or content were observed between uremic patients and controls.
    • CaBP levels correlated directly with 25-OHD but not with parathormone levels.

    Conclusions:

    • Intestinal CaBP is normal in activity, quantity, and calcium affinity in malabsorbing uremic patients.
    • Calcium malabsorption in uremia appears unrelated to a deficiency in intestinal calcium binding protein.
    • These findings suggest that vitamin D responsiveness in uremia is not limited by intestinal CaBP levels.

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