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Updated: Aug 4, 2026

Neuro-rehabilitation Approach for Sudden Sensorineural Hearing Loss
Published on: January 25, 2016
[Otosclerosis and Van der Hoeven's syndrome: a contribution]
L A Vallejo Valdezate1, J Martín Gil, M José-Yacamán
1Servicio de ORL, Hospital Universitario Río Hortega, C/Cardenal Torquemada, s/n. 47010 Valladolid.
Abstract:
Morphological and microchemical changes that effect to the otosclerotic stape in the Van der Hoeve's syndrome were examined with a scanning electron microscope equipped with an energy dispersive X-ray fluorescence. Using the Ca/P ratio as criterion--measured by the characteristic x-ray fluorescence--it was shown that the Van der Hoeve stape had a higher Ca/P ratio (2.6:1) as compared to the normal stape (2:1). The Van der Hoeve's syndrome lesions as poorly mineralized, with low calcium salt and apparent increase of phosphates. This finding indicates a possible change from hydroxyapatite (or apatite) to brushite, which imply an acidification of bone.
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