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Related Experiment Videos

Adenosine-induced ventricular fibrillation.

C P Shah1, A K Gupta, R K Thakur

  • 1KEM Hospital, Parel, Mumbai, India.

Indian Heart Journal
|June 29, 2001
PubMed
Summary

Adenosine can accelerate heart rate during atrial fibrillation, potentially causing ventricular fibrillation. This study observed two cases of ventricular fibrillation after adenosine administration in patients with pre-excited atrial fibrillation.

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Area of Science:

  • Cardiology
  • Electrophysiology
  • Pharmacology

Background:

  • Adenosine is a suggested diagnostic tool for wide QRS complex tachycardia.
  • Adenosine's effect on accessory atrioventricular connections and atrial fibrillation requires careful consideration.

Observation:

  • Two patients presented with pre-excited atrial fibrillation.
  • Both patients received 12 mg of adenosine in the emergency department.

Findings:

  • Adenosine administration led to ventricular fibrillation in both observed patients.
  • This suggests a potential risk of adenosine in pre-excited atrial fibrillation.

Implications:

  • Clinicians should exercise caution when using adenosine in patients with pre-excited atrial fibrillation.

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  • Further research is needed to understand adenosine's proarrhythmic potential in specific cardiac conditions.