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Preparation of regular sized Ca-alginate microspheres using membrane emulsification method.

J O You1, S B Park, H Y Park

  • 1Department of Chemical Engineering, College of Engineering and Bioproducts Research Center, Yonsei University, Seoul, Korea.

Journal of Microencapsulation
|June 29, 2001
PubMed
Summary

This study prepared uniform calcium-alginate microspheres using membrane emulsification. Drug release rates depended on drug ionic type and release medium acidity, with cationic drugs showing slower release due to electrostatic interactions.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Chemical Engineering

Background:

  • Calcium-alginate microspheres are widely used for drug delivery.
  • Controlling microsphere properties and drug release is crucial for effective therapeutics.

Purpose of the Study:

  • To prepare monodisperse calcium-alginate microspheres using membrane emulsification.
  • To investigate the influence of drug ionic type and release conditions on drug release kinetics.

Main Methods:

  • Membrane emulsification technique was employed for microsphere preparation.
  • Varying sodium alginate concentrations and pressures were tested to optimize microsphere size.
  • Anionic, cationic, and non-ionic model drugs were incorporated into the microspheres.

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Main Results:

  • Monodisperse calcium-alginate microspheres (approx. 4 µm) were achieved at 2 wt% alginate and 0.4 x 10(5) Pa pressure.
  • Cationic drug release was significantly retarded compared to anionic drugs due to electrostatic attraction.
  • Acidic release media resulted in slow drug release for all ionic types due to alginate swelling and viscosity changes.

Conclusions:

  • Membrane emulsification is effective for producing uniform calcium-alginate microspheres.
  • Drug release from these microspheres is controllable by drug charge and environmental pH.
  • The findings provide insights for designing advanced drug delivery systems.