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Updated: Jul 29, 2026
18:48
Murine Renal Transplantation Procedure
Published on: July 10, 2009
Tuberculosis in renal transplant recipients
1Instituto de Nefrología, Buenos Aires, Argentina. kurlat@datamarkets.com.ar
Summary
Tuberculosis (TB) is a significant risk for kidney transplant recipients. Early diagnosis and careful immunosuppression management are key to successful patient and graft outcomes in these vulnerable individuals.
Area of Science:
- Nephrology
- Infectious Diseases
- Transplantation Immunology
Background:
- Tuberculosis (TB) in kidney transplant recipients often presents with pulmonary involvement.
- Understanding the impact of TB on kidney transplantation is crucial for patient care.
Purpose of the Study:
- To analyze the incidence, clinical presentation, diagnostic methods, and outcomes of tuberculosis in adult kidney transplant recipients.
- To evaluate the relationship between TB, immunosuppressive therapy, and graft survival.
Main Methods:
- Retrospective analysis of clinical records of 384 adult kidney transplant recipients transplanted between 1986 and 1995.
- Inclusion criteria excluded patients with prior TB or early graft loss; analysis included demographics, immunosuppression, TB sites, diagnostics, and outcomes.
- Tuberculin skin test (PPD) status, time to onset, and concomitant infections were also assessed.
Main Results:
- Tuberculosis was diagnosed in 14 recipients (3.64%), with a mean age of 35 years; 10 had pulmonary TB.
- Mycobacterium tuberculosis cultures were positive in all cases; invasive diagnostic procedures were used in 13.
- At one year post-TB diagnosis, graft survival was 72.7% and patient survival was 90.9%; TB was more common in PPD-positive recipient-donor pairs.
Conclusions:
- Tuberculosis poses a growing threat in kidney transplantation.
- Early, aggressive diagnosis and vigilant immunosuppression monitoring are essential for favorable patient and graft outcomes.
- Further research is needed to define optimal prophylaxis guidelines for TB in transplant recipients.
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