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Antifeedant constituents from Fagara macrophylla.
C Tringali1, C Spatafora, V Calì
1Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, Catania I-95125, Italy. ctringali@dipchi.unict.it
Fitoterapia
|June 29, 2001
Summary
The African plant Fagara macrophylla yielded alkaloids and a flavonoid. Xanthoxoline showed potent antifeedant activity against Spodoptera larvae, with other compounds also exhibiting activity.
Area of Science:
- Phytochemistry
- Ethnobotany
- Insect Toxicology
Background:
- Fagara macrophylla is an African medicinal plant with a rich chemical profile.
- Previous research has identified various metabolites from this plant.
- Understanding the bioactivity of these compounds is crucial for potential applications.
Purpose of the Study:
- To isolate and identify compounds from the bark of Fagara macrophylla.
- To evaluate the antifeedant activity of these isolated compounds against insect pests.
- To identify potential natural pest control agents.
Main Methods:
- Extraction of Fagara macrophylla bark using ethanol.
- Isolation and identification of alkaloids and flavonoids using chromatographic and spectroscopic techniques.
- Antifeedant activity testing using a binary-choice bioassay with Spodoptera frugiperda and Spodoptera littoralis larvae.
Main Results:
- Oblongine, tembetarine, magnoflorine, and hesperidin were isolated and identified.
- Xanthoxoline demonstrated potent antifeedant activity against both Spodoptera frugiperda and Spodoptera littoralis.
- 1-Hydroxy-3-methoxy-N-methyl-acridone, arborinine, tembetarine, and magnoflorine showed antifeedant activity against Spodoptera frugiperda.
Conclusions:
- Fagara macrophylla bark contains bioactive alkaloids with significant antifeedant properties.
- Xanthoxoline is a promising candidate for natural insecticide development.
- Further research into the mechanism of action and efficacy of these compounds is warranted.