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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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A preliminary study on the analgesic activity of Grangea maderaspatana

M Ahmed1, M M Islam, C F Hossain

  • 1Department of Pharmacy, University of Dhaka, Dhakka 1000, Bangladesh. mmn@bpl.net

Fitoterapia
|June 29, 2001
PubMed

Abstract:

The methanol extract of the whole plant of Grangea maderaspatana showed a dose-dependent analgesic activity. At doses of 1 and 3 g/kg, the extract significantly (P<0.001) inhibited acetic acid-induced writhing in mice by 50 and 80%, respectively.

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...

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