Related Experiment Videos
Nutritional efficacy of preterm formula with a partially hydrolyzed protein source: a randomized pilot study
J C Picaud1, J Rigo, S Normand
1Neonatology and Human Nutrition Research Center, Edouard Herriot Hospital, Claude Bernard University, Place d'Arsonval, 69437 Lyon Cedex 03, France. jean-charles.picaud@chu-lyon.fr
Journal of Pediatric Gastroenterology and Nutrition
|June 29, 2001
Summary
This pilot study evaluated a new partially hydrolyzed formula for preterm infants, finding it comparable in nitrogen retention and plasma amino acids to conventional formula, though growth was lower. Further research is needed.
Area of Science:
- Neonatal nutrition
- Pediatric gastroenterology
- Infant formula development
Background:
- Partially hydrolyzed preterm formulas were associated with decreased nitrogen levels, calcium absorption, and plasma amino acid imbalances.
- A novel formula with modified nitrogen and calcium sources was developed to address these concerns.
Purpose of the Study:
- To evaluate a new partially hydrolyzed formula in preterm infants.
- To compare nutrient balance, plasma amino acid concentrations, and anthropometric parameters with a conventional formula.
Main Methods:
- A pilot study involving 16 preterm infants randomly assigned to receive either the new formula or a conventional formula.
- Nutrient balance, plasma amino acid concentrations, and anthropometric measurements were assessed.
Main Results:
- Nitrogen absorption rates were lower with the new formula, but nitrogen retention was similar after adjustment for intake.
- Plasma amino acid profiles were comparable between groups.
- Calcium absorption tended to be higher with the new formula, but infants fed the conventional formula had higher birth weights and were heavier at theoretical term.
Conclusions:
- The new partially hydrolyzed formula may achieve appropriate nitrogen retention, plasma amino acid profiles, and mineral utilization.
- Despite higher nitrogen content, the modified formula shows potential, but further studies are required to assess its impact on growth.