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Asymmetric synthesis of umuravumbolide
M V Reddy1, J P Rearick, N Hoch
1Herbert C. Brown Center for Borane Research, Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-1393, USA.
Organic Letters
|June 30, 2001
Abstract:
[figure: see text] This first asymmetric synthesis of enantiopure desacetylumuravumbolide and umuravumbolide via asymmetric reduction, allylboration, and ring-closing metathesis confirms their revised structures and configurations. A convenient procedure to upgrade the enantiopurity of alpha,beta-acetylenic alcohols is also described.