Related Experiment Video
Updated: Aug 14, 2026

Assessment of Dictyostelium discoideum Response to Acute Mechanical Stimulation
Published on: November 9, 2017
Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity
S P Gunasekera1, R E Longley, R A Isbrucker
1Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, USA. sgunaseker@hboi.edu
Abstract:
A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured murine P-388 leukemia cells. The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described.
Related Concept Videos
Destabilization of Microtubules
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules
Anthelminthic Agents

