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A novel anti-HIV macrocyclic peptide from Palicourea condensata
H R Bokesch1, L K Pannell, P K Cochran
1Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
Journal of Natural Products
|June 30, 2001
Abstract:
A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.