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The first total synthesis of (+/-)-eremopetasidione
1Department of Chemistry, National Tsing Hua University, Hsinchu-300, Taiwan.
Organic Letters
|June 30, 2001
Abstract:
[figure: see text] The total synthesis of racemic eremopetasidione, a norsesquiterpenoid, has been achieved in nine steps and 30% overall yield starting from creosol (5). Diels-Alder reaction of masked o-benzoquinone 6 and ethyl vinyl ketone and Cope rearrangement of 2-silyloxy-1,5-dienone 3 are the key steps.