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Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays
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Threshold analysis of selected dose-response data for endocrine active chemicals

R M Blair1, H Fang, D Gaylor

  • 1Division of Genetic and Reproductive Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR 72079, USA.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|June 30, 2001
PubMed
Summary

This study used the Michaelis-Menten equation to analyze endocrine-disrupting chemical data, finding that biological responses often lack a threshold dose. The modified model effectively describes dose-response curves for these chemicals.

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