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Efficacy of a packaged rice oral rehydration solution among children with cholera and cholera-like illness

K Zaman1, M Yunus, A Rahman

  • 1The International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. kzaman@icddrb.org

Acta Paediatrica (Oslo, Norway : 1992)
|June 30, 2001
PubMed

Insights

A new rice oral rehydration solution (ORS) packet, CeraLyte-90, effectively treated cholera and cholera-like diarrhea in Bangladeshi boys. This rice-based ORS demonstrated safety and efficacy, reducing stool output in the initial treatment phase.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Rice-based oral rehydration solution (ORS) has shown promise in reducing purging rates and illness duration for cholera patients.
  • A new packet form of rice ORS, CeraLyte-90, was developed for improved accessibility and administration.

Purpose of the Study:

  • To evaluate the safety and efficacy of CeraLyte-90 compared to traditional glucose-based ORS in children with acute dehydrating cholera and cholera-like diarrhea.
  • To assess key clinical and laboratory parameters including stool output, duration of diarrhea, and serum electrolyte levels.

Main Methods:

  • A randomized controlled trial was conducted with 167 boys aged 5-15 years in Bangladesh.
  • Patients received either CeraLyte-90 or glucose ORS, along with early feeding and antibiotics.
  • Efficacy was measured by comparing stool output, diarrhea duration, hematocrit, serum electrolytes, and need for intravenous fluids.

Main Results:

  • The rice ORS group showed a statistically significant 20% reduction in stool output during the first 8 hours of treatment (p < 0.05).
  • While stool output was similar in other periods, the rice ORS group experienced slightly more vomiting on day one (p < 0.05).
  • Serum electrolyte concentrations remained within normal ranges for both groups throughout the study.

Conclusions:

  • The new, packaged rice ORS (CeraLyte-90) is safe and effective for treating children with cholera and cholera-like diarrhea.
  • Rice-based ORS offers a viable alternative to glucose-based solutions, particularly in resource-limited settings.
  • Further research may explore optimal formulations and broader applicability of rice ORS.
Abstract

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