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Ranitidine-induced acute interstitial nephritis in a cadaveric renal allograft
O E Emovon1, J A King, C O Holt
1Departments of Medicine, Pathology, and Surgery, University of South Alabama, Mobile, AL, USA. oemovon@usamail.usouthal.edu
Summary
Ranitidine can cause acute interstitial nephritis in kidney transplant recipients, leading to sudden allograft dysfunction. Prompt drug withdrawal rapidly restored kidney function in a reported case.
Area of Science:
- Nephrology
- Transplantation Immunology
- Pharmacology
Background:
- Ranitidine is commonly used to prevent peptic ulceration post-renal transplant.
- Acute interstitial nephritis (AIN) is a known, albeit rare, side effect of ranitidine in native kidneys.
- Reports linking ranitidine to AIN in renal allografts are notably absent.
Observation:
- A patient receiving a cadaveric renal allograft developed acute allograft dysfunction within 48 hours of ranitidine administration.
- Renal biopsy revealed characteristic features of acute interstitial nephritis, including eosinophilic infiltration.
Findings:
- The case demonstrates ranitidine-induced acute interstitial nephritis in a renal allograft recipient.
- Histopathological examination confirmed pathognomonic signs of drug-induced interstitial nephritis.
Implications:
- This case highlights a potential adverse drug reaction to ranitidine in renal transplant recipients.
- Early recognition and cessation of ranitidine may be crucial for preserving allograft function.
- Clinicians should consider ranitidine as a potential cause of acute allograft dysfunction.