Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Dysfunction of early-stage visual processing in schizophrenia.

P D Butler¹, I Schechter, V Zemon

¹Department of Veterans Affairs New York Harbor Health Care System, New York, New York, USA. butler@nki.rfmh.org

The American Journal of Psychiatry

|June 30, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex?

bioRxiv : the preprint server for biology·2024

Same author

Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers.

Schizophrenia research·2023

Same author

Parcel-guided rTMS for depression.

Translational psychiatry·2020

Same author

Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression.

Scientific reports·2019

Same author

Neural mechanisms of mismatch negativity dysfunction in schizophrenia.

Molecular psychiatry·2017

Same author

Multi-Scale Entrainment of Coupled Neuronal Oscillations in Primary Auditory Cortex.

Frontiers in human neuroscience·2015

Same journal

Social Determinants of Health in Psychiatric Disorders: Exciting Opportunities for Biopsychosocial Research and Clinical Care.

The American journal of psychiatry·2026

Same journal

Association of Fetal Gene Regulatory Gene Deletions With Poor Cognition in Schizophrenia and Community-Based Samples.

The American journal of psychiatry·2026

Same journal

Circadian Rhythm Stabilization App to Prevent Mood Episode Recurrence in Patients With Mood Disorders: A Multicenter, Double-Blind, Sham-Controlled, Randomized Clinical Trial.

The American journal of psychiatry·2026

Same journal

Neurocognitive Development in Adolescent Offspring at Familial High Risk of Schizophrenia or Bipolar Disorder and a Population-Based Control Group.

The American journal of psychiatry·2026

Same journal

A Pragmatic SMART Study of Medication and CBT Sequencing in Pediatric Anxiety Disorders: A Randomized Clinical Trial.

The American journal of psychiatry·2026

Same journal

Deadly Heat: The Association Between Ambient Temperature and Suicide in Young People in the United States.

The American journal of psychiatry·2026

See all related articles

Patients with schizophrenia exhibit visual processing deficits, particularly in the magnocellular pathway, impacting their ability to orient towards stimuli. This early visual dysfunction may contribute to higher-level cognitive impairments in schizophrenia.

Area of Science:

Neuroscience
Visual Processing
Psychiatry

Background:

Schizophrenia is characterized by higher-order visual processing deficits.
Understanding early visual pathway integrity is crucial for a comprehensive view of visual dysfunction in schizophrenia.

Purpose of the Study:

To evaluate the integrity of early visual processing in schizophrenia.
To determine the pattern of visual dysfunction by examining magnocellular and parvocellular pathway activity.

Main Methods:

Recorded steady-state visual-evoked potential (VEP) responses in schizophrenia patients and controls.
Utilized stimuli modulated in luminance contrast, number, and chromatic contrast to target magnocellular or parvocellular pathways.

Main Results:

Related Experiment Videos

Schizophrenia patients showed significantly lower VEP responses to magnocellular-biased stimuli (low contrast, large squares).
Responses to parvocellular-biased stimuli did not differ significantly between groups.
A significant interaction between group and stimulus type was noted under low luminance contrast conditions.

Conclusions:

Findings indicate dysfunction in lower-level visual pathways in schizophrenia, more pronounced for magnocellular-biased stimuli.
Deficits in the magnocellular pathway, crucial for orienting to salient stimuli, may underlie higher-level visual cognitive impairments in schizophrenia.