Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Dysfunction of early-stage visual processing in schizophrenia.

P D Butler¹, I Schechter, V Zemon

¹Department of Veterans Affairs New York Harbor Health Care System, New York, New York, USA. butler@nki.rfmh.org

The American Journal of Psychiatry

|June 30, 2001

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Is there a ubiquitous spectrolaminar motif of local field potential power across primate neocortex?

bioRxiv : the preprint server for biology·2024

Same author

Validation of a suite of ERP and QEEG biomarkers in a pre-competitive, industry-led study in subjects with schizophrenia and healthy volunteers.

Schizophrenia research·2023

Same author

Parcel-guided rTMS for depression.

Translational psychiatry·2020

Same author

Resting state functional connectivity predictors of treatment response to electroconvulsive therapy in depression.

Scientific reports·2019

Same author

Neural mechanisms of mismatch negativity dysfunction in schizophrenia.

Molecular psychiatry·2017

Same author

Multi-Scale Entrainment of Coupled Neuronal Oscillations in Primary Auditory Cortex.

Frontiers in human neuroscience·2015

Same journal

2026 Annual Meeting: President-Elect Address.

The American journal of psychiatry·2026

Same journal

2026 Annual Meeting: CEO and Medical Director's Address.

The American journal of psychiatry·2026

Same journal

Reports to the Membership.

The American journal of psychiatry·2026

Same journal

Convergent Metabolic Dysregulations But Divergent Contributing Pathways Across Severe Mental Disorders: The Power of Combining Genetics and Metabolomics.

The American journal of psychiatry·2026

Same journal

2026 Annual Meeting: Presidential Address.

The American journal of psychiatry·2026

Same journal

Represcribing Previously Used Antipsychotics: Response to So.

The American journal of psychiatry·2026

See all related articles

Patients with schizophrenia exhibit visual processing deficits, particularly in the magnocellular pathway, impacting their ability to orient towards stimuli. This early visual dysfunction may contribute to higher-level cognitive impairments in schizophrenia.

Area of Science:

Neuroscience
Visual Processing
Psychiatry

Background:

Schizophrenia is characterized by higher-order visual processing deficits.
Understanding early visual pathway integrity is crucial for a comprehensive view of visual dysfunction in schizophrenia.

Purpose of the Study:

To evaluate the integrity of early visual processing in schizophrenia.
To determine the pattern of visual dysfunction by examining magnocellular and parvocellular pathway activity.

Main Methods:

Recorded steady-state visual-evoked potential (VEP) responses in schizophrenia patients and controls.
Utilized stimuli modulated in luminance contrast, number, and chromatic contrast to target magnocellular or parvocellular pathways.

Main Results:

Related Experiment Videos

Schizophrenia patients showed significantly lower VEP responses to magnocellular-biased stimuli (low contrast, large squares).
Responses to parvocellular-biased stimuli did not differ significantly between groups.
A significant interaction between group and stimulus type was noted under low luminance contrast conditions.

Conclusions:

Findings indicate dysfunction in lower-level visual pathways in schizophrenia, more pronounced for magnocellular-biased stimuli.
Deficits in the magnocellular pathway, crucial for orienting to salient stimuli, may underlie higher-level visual cognitive impairments in schizophrenia.