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Updated: Aug 14, 2026
07:20
Inducement and Evaluation of a Murine Model of Experimental Myopia
Published on: January 22, 2019
Tropicamide (1%): an effective cycloplegic agent for myopic children
R E Manny1, M Hussein, M Scheiman
1College of Optometry, University of Houston, 505 J. Davis Armistead Bldg., Houston, TX 77204-2020, USA. rmanny@uh.edu
Investigative Ophthalmology & Visual Science
|June 30, 2001
Summary
One percent tropicamide effectively induces cycloplegia in children with myopia. This study found the drug
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Clinical Trials
Background:
- Myopia is a common refractive error in children.
- Accurate refractive error assessment is crucial for myopia management.
- Cycloplegic agents are used to relax accommodation for precise refraction.
Purpose of the Study:
- To assess the efficacy of 1% tropicamide as a cycloplegic agent in myopic children.
- To investigate potential associations between tropicamide's efficacy and demographic or refractive factors.
Main Methods:
- A multicenter, randomized, double-masked trial involving 469 myopic children.
- Administration of proparacaine followed by two drops of 1% tropicamide.
- Measurement of accommodative responses using an autorefractor to determine residual accommodation.
Main Results:
- 1% tropicamide demonstrated a significant cycloplegic effect in myopic children.
- Mean residual accommodation was minimal (0.38 D OD, 0.30 D OS).
- Ethnicity showed a statistically significant association with residual accommodation, unlike other factors.
Conclusions:
- 1% tropicamide is a safe and effective cycloplegic agent for refractive examination in pediatric myopia.
- The findings support the use of tropicamide for cycloplegic refraction in this population.
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