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Antibody Transfection into Neurons as a Tool to Study Disease Pathogenesis
Published on: September 26, 2012
[Autoimmune peripheral neuropathies with anti-MAG antibodies and hematological disorders. Five cases]
E Andrès1, S Vinzio, F Maloisel
1Services de Médecine Interne et Nutrition, Clinique Médicale B, Hôpital, 67091 Strasbourg Cedex, France.
Objective:
The aim of this study was to report our experience with autoimmune neuropathies associated with hematological disorders and to describe their etiological and clinical polymorphism.
Patients And Methods:
A retrospective study was conducted in five patients with autoimmune peripheral neuropathies with anti-MAG (myelin-associated glycoprotein) antibodies.
Results:
Autoimmune neuropathies were associated with Waldenström's macroglobulinemia (n=2), Hodgkin disease (n=1), chronic lymphocytic leukemia (n=1) and idiopathic polyclonal B lymphoproliferation (n=1). Most of the patients had a sensorial polyneuropathy, predominant in the legs, exhibiting slow progress. Our patients showed a disappointing response to chemotherapy with stabilization or short response.
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