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Dysgerminoma associated with hypercalcemia: A case report.

B O Okoye1, C Harmston, R G Buick

  • 1Department of Paediatric Surgery, Birmingham Children's Hospital, Birmingham, England.

Journal of Pediatric Surgery
|June 30, 2001
PubMed
Summary

Hypercalcemia is a rare paraneoplastic syndrome in pediatric cancers. Surgical removal of ovarian dysgerminoma resolved severe hypercalcemia in a teen, highlighting the importance of checking calcium in similar cases.

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Area of Science:

  • Pediatric Oncology
  • Endocrinology
  • Gynecologic Oncology

Background:

  • Hypercalcemia is an uncommon paraneoplastic manifestation in pediatric malignancies.
  • Ovarian tumors, particularly dysgerminomas, can present with significant hypercalcemia.

Observation:

  • A case study of a 14-year-old girl with dysgerminoma and severe hypercalcemia is presented.
  • The hypercalcemia was refractory to medical management.

Findings:

  • Tumor excision led to the resolution of hypercalcemia, confirming the paraneoplastic etiology.
  • This case adds to the limited reported instances of dysgerminoma-associated hypercalcemia (7 total cases including this one).

Implications:

  • Routine serum calcium monitoring is crucial for pediatric patients diagnosed with solid ovarian tumors.

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  • Surgical resection should be considered as a primary treatment for resolving paraneoplastic hypercalcemia in these cases.