Related Experiment Video
Updated: Jul 17, 2026

Assessing Leukocyte-endothelial Interactions Under Flow Conditions in an Ex Vivo Autoperfused Microflow Chamber Assay
Published on: December 30, 2014
My life and times with enzymes and mediators
1The William Harvey Research Foundation, The William Harvey Research Institute, London, UK. c.l.measures@mds.qmw.ac.uk
Abstract:
The vascular endothelium plays a vital role in the control of the circulation. It metabolises various vasoactive substances, converts angiotensin I to angiotensin II and secretes the potent vasodilator prostacyclin, as well as nitric oxide and endothelin-1. The balance between these mediators determines the response of the cardiovascular system in diseases such as hypertension, atherosclerosis and myocardial infarction. In this article I describe some of my work over the past 50 years. In the process, I hope to show that it is not only Princes who travel the road to Serendip but also Scientists. The application of simple methods, luck, happy coincidences, serendipity and noticing the unusual have all played an important role in my scientific career. However, the choice of colleagues has also been vital.
Related Concept Videos
Enzyme Kinetics
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
Introduction to Enzymes
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that bind the substrates and convert them into products. Many enzymes also...
Enzymes and Activation Energy
Introduction to Enzyme Kinetics
The experimenter can then plot the initial reaction rate or velocity (Vo) of a given trial against the substrate concentration ([S]) to obtain a graph of the reaction properties. For many enzymatic reactions involving a...
Introduction To Enzymes
Most enzymes are proteins that speed up biochemical reactions without being consumed. Enzymes contain one or more active sites that bind the substrates and convert them into products. Many enzymes also...
Enzymes and Activation Energy

