Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The evolution of isochores.

A Eyre-Walker1, L D Hurst

  • 1Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton BN1 9QG, UK. a.c.eyre-walker@sussex.ac.uk

Nature Reviews. Genetics
|July 4, 2001
PubMed
Summary

Mammalian genomes exhibit an isochore structure, characterized by variations in G+C content across large DNA segments. This review examines the leading hypotheses attempting to explain the functional significance of these genomic isochores.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DNA sequence diversity and the efficiency of natural selection in animal mitochondrial DNA.

Heredity·2016
Same author

Covert sex.

Trends in ecology & evolution·2011
Same author

Sex-ratio adjustment in solitary and social spiders.

Trends in ecology & evolution·2011
Same author

Intranuclear conflict and its role in evolution.

Trends in ecology & evolution·2011
Same author

Recent advances in understanding of the evolution and maintenance of sex.

Trends in ecology & evolution·2011
Same author

Riding the evolutionary streetcar: where population genetics and game theory meet.

Trends in ecology & evolution·2011

Area of Science:

  • Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Mammalian chromosomes display significant variations in Guanine-Cytosine (G+C) content over large scales (kilobases to megabases).
  • These variations define the 'isochore' structure, impacting both coding and non-coding genomic regions.
  • The fundamental organization and evolutionary drivers of isochores remain poorly understood despite decades of research.

Purpose of the Study:

  • To review and synthesize the current evidence supporting major hypotheses on the existence and function of genomic isochores.
  • To provide an overview of the proposed explanations for the observed G+C content variation in mammalian genomes.

Main Methods:

  • Literature review of existing research on mammalian genome isochore structure.
  • Analysis and comparison of evidence for different hypotheses explaining isochore formation and function.

Main Results:

  • The review consolidates data related to isochore structure and its impact on genome organization.
  • Evidence for three primary hypotheses regarding the origin and role of isochores is presented and discussed.

Conclusions:

  • Understanding the 'why' behind isochores is crucial for a comprehensive view of genome organization.
  • Further research is needed to definitively elucidate the evolutionary and functional significance of isochores in mammalian genomes.

Related Experiment Videos