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Updated: Jul 13, 2026

Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro
Published on: January 11, 2017
How proteins move lipids and lipids move proteins
H Sprong1, P van der Sluijs, G van Meer
1Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam.
Abstract:
Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.
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