[Development of the central nervous system in mammals]

In humans, the nervous system is induced during the third gestational week by molecular signals coming from the mesoderm, which modulate the temporal and spatial expression of specific genes in the cells of the dorsal ectoderm. The induced neural plate closes to form the neural tube where the cells actively proliferate in the germinal zone. The neuroblasts which have completed their last division migrate along the fibers of the radial glia to which they adhere, and this movement is essential to establish the normal cerebral organization. The regional identity of the developing brain is governed by the expression of homeobox genes, and the main central structures are clearly delineated by the end of the fifth week. The cerebral cortex begins to form on the seventh week, and the early specification of the cortical areas, which is under genetic control, would be modulated later on by environmental influences. When the neurons have reached their final position, they extend an axon, using surface molecules or diffusible molecules present along its pathway as cues to reach the appropriate target and form a synapse, and this process is a critical step for the establishment of neuronal relationships. The maturation and stabilization of neural networks is characterized by the apoptotic death of roughly 50% of the neurons, due to insufficient neurotrophic support, and by the remodeling of the initial synaptic connections in the surviving neurons. These regressive events occur late in development and depend on both the interactions with the environment and the resulting neuronal activity.