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[Merkel cell carcinoma].

M Policarpo1, P Aluffi, R Dosdegani

  • 1Clinica ORL, Dipartimento di Scienze Mediche, Università del Piemonte Orientale A. Avogadro, Novara.

Acta Otorhinolaryngologica Italica : Organo Ufficiale Della Societa Italiana Di Otorinolaringologia E Chirurgia Cervico-Facciale
|July 4, 2001
PubMed
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Merkel cell carcinoma, a rare and aggressive head and neck cancer, presents unique diagnostic and treatment challenges. Despite aggressive treatment including surgery and radiotherapy, frequent recurrence remains a significant concern for patients.

Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine skin cancer.
  • It predominantly affects the head and neck region.
  • MCC shares characteristics with small cell tumors, exhibiting high metastatic potential and recurrence rates.

Observation:

  • The study details two cases of head and neck Merkel cell carcinoma.
  • It evaluates the specific characteristics and clinical evolution of these cases.
  • Diagnostic methods include electron microscopy and immunohistochemistry for neurofilaments and cytokeratin 20.

Findings:

  • MCC demonstrates a tendency for significant lymph node and blood metastasis.
  • Frequent recurrence is observed even after comprehensive treatment.

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  • Radical surgery with a 3 cm tumor-free margin and adjuvant radiotherapy is the current standard treatment.

    • Implications:

    • Early and accurate diagnosis is crucial for effective management of MCC.
    • Despite current therapeutic strategies, managing MCC recurrence remains a clinical challenge.
    • Further research into novel therapeutic approaches may improve outcomes for head and neck MCC.