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Lupus flare associated with growth hormone
1Department of Internal Medicine, Hanyang University College of Medicine and the Hospital for Rheumatic Diseases, Seoul, Korea.
Lupus
|July 4, 2001
Summary
Growth hormone (GH) therapy can trigger lupus flares in patients with systemic lupus erythematosus (SLE). Discontinuation of GH and immunosuppressive treatment led to disease improvement.
Area of Science:
- Endocrinology
- Rheumatology
- Immunology
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease.
- Growth hormone (GH) is used to treat growth retardation.
- The potential impact of GH on SLE activity is not fully understood.
Observation:
- A young male patient with an 11-year history of SLE experienced a lupus flare.
- The flare occurred after 9 months of GH treatment for growth retardation.
- Disease activity improved upon cessation of GH and initiation of immunosuppressive therapy.
Findings:
- Growth hormone administration may exacerbate systemic lupus erythematosus.
- High-dose corticosteroids and intravenous cyclophosphamide are effective in managing GH-induced lupus flares.
- GH therapy should be approached with caution in SLE patients.
Implications:
- This case highlights a potential adverse effect of GH therapy in SLE patients.
- Further research is needed to elucidate the mechanisms underlying GH's effect on SLE.
- Clinical monitoring for lupus activity is crucial during GH treatment in susceptible individuals.