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Related Experiment Videos

Post-prandial decrease of circulating human ghrelin levels.

M Tschöp1, R Wawarta, R L Riepl

  • 1Medizinische Klinik Innenstadt, Ludwig-Maximilians Universität, Munich, Germany.

Journal of Endocrinological Investigation
|July 4, 2001
PubMed
Summary
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Nutrient intake lowers ghrelin levels in humans. Fasting ghrelin levels correlate with gastric emptying, suggesting ghrelin signals nutrient status to the brain.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Neuroscience

Background:

  • Ghrelin, a GH secretagogue-receptor ligand, influences GH secretion, appetite, and fat storage.
  • Human ghrelin regulation and function, particularly concerning gastric motility, are not well understood.

Purpose of the Study:

  • To investigate the impact of nutrient intake on human ghrelin levels.
  • To explore the association between ghrelin levels and gastric emptying in healthy individuals.

Main Methods:

  • Ten healthy volunteers participated after an overnight fast.
  • A standard meal was administered, followed by measurements of plasma ghrelin levels.
  • Gastric emptying was assessed using a non-invasive 13C-octanoic acid breath test.

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Main Results:

  • Food intake significantly reduced plasma ghrelin levels post-meal (p=0.047).
  • Fasting plasma ghrelin levels showed a strong correlation with gastric emptying half-time (r=0.74, p=0.0013).

Conclusions:

  • Ghrelin levels decrease after nutrient intake in humans.
  • Ghrelin may act as a feedback signal linking nutrient consumption, gastric function, and central nervous system regulation.