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Intermittent claudication: effective medical management of a common circulatory problem
1University of Michigan Medical School, Ann Arbor, Michigan, USA. hbeebe@jvc.org
The American Journal of Cardiology
|July 4, 2001
Summary
Intermittent claudication (IC) treatment is recommended due to its link to systemic atherosclerosis. Cilostazol significantly improves walking distance in IC patients, outperforming pentoxifylline.
Area of Science:
- Vascular Medicine
- Pharmacology
Background:
- Intermittent claudication (IC) is a common symptom of lower-extremity peripheral arterial occlusive disease, often indicating systemic atherosclerosis.
- Current management involves risk-factor modification, exercise, and pharmacotherapy, though outcomes can be variable.
Purpose of the Study:
- To review the efficacy of pharmacotherapies for intermittent claudication.
- To compare cilostazol and pentoxifylline in treating IC symptoms.
Main Methods:
- Review of clinical trials and pharmacotherapy options for intermittent claudication.
- Comparison of cilostazol and pentoxifylline efficacy based on walking distance improvements.
Main Results:
- Cilostazol demonstrated significant effectiveness, generally doubling maximal walking distance in IC patients at 24 weeks.
- Cilostazol proved more effective than pentoxifylline in enhancing both pain-free and maximal walking distances.
Conclusions:
- Cilostazol is a highly effective pharmacotherapy for managing intermittent claudication.
- While other treatments like platelet antiaggregants and revascularization exist, cilostazol offers a significant improvement in walking capacity for IC patients.
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