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Related Experiment Videos

Is cellular fibronectin a biological marker for pre-eclampsia?

D Islami1, Y Shoukir, P Dupont

  • 1Department of Obstetrics and Gynaecology, Clinic of Infertility and Gynaecological Endocrinology, WHO Collaborating Centre in Human Reproduction, University Hospital of Geneva, 32 Boulevard de la Cluse, 1211 Geneva, Switzerland. dorina.islami@hcuge.ch

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|July 4, 2001
PubMed
Summary

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Cellular fibronectin (cFn) levels rise during pregnancy, with a significant increase observed after 36 weeks. Elevated cFn in the third trimester is linked to pre-eclampsia, but it cannot predict the condition.

Area of Science:

  • Obstetrics and Gynecology
  • Cell Biology
  • Biochemistry

Background:

  • Cellular fibronectin (cFn) is synthesized by endothelial cells and elevated levels suggest endothelial damage.
  • Pre-eclampsia is a pregnancy complication characterized by endothelial cell pathology.
  • Understanding cFn dynamics during pregnancy is crucial for investigating pre-eclampsia.

Purpose of the Study:

  • To investigate longitudinal changes in circulating cellular fibronectin (cFn) during pregnancy.
  • To determine if cFn levels are elevated in pregnancies complicated by pre-eclampsia.
  • To identify the gestational timing of cFn alterations in normal and pre-eclamptic pregnancies.

Main Methods:

  • Longitudinal study of 198 pregnant patients.
  • Measurement of cFn concentrations using ELISA with monoclonal antibody A 134 at four time points during pregnancy.

Related Experiment Videos

  • Comparison of cFn values between women who developed pre-eclampsia and those with normal pregnancies.

    • Main Results:

    • cFn concentrations increased throughout normal pregnancy, with a significant rise after 36 weeks.
    • Doubling time of cFn decreased as concentrations increased, indicating an inverse relationship.
    • Third-trimester cFn levels were significantly higher in women who developed pre-eclampsia (3.53 microg/ml) compared to normal pregnancies (2.23 microg/ml).

    Conclusions:

    • Circulating cFn levels increase progressively during normal pregnancy, particularly after 36 weeks.
    • Elevated cFn in the third trimester is associated with pre-eclampsia.
    • cFn cannot serve as a predictive marker for pre-eclampsia due to symptom onset coinciding with measurement.
    • This study provides the first longitudinal data on cFn changes in normal and pre-eclamptic pregnancies.