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Related Experiment Videos

Partial cystectomy during radical surgery for nonurological malignancy.

R P Weinstein1, B M Grob, E M Pachter

  • 1Department of Urology, State University Health Science Center at Brooklyn, New York, USA.

The Journal of Urology
|July 4, 2001
PubMed
Summary

Partial cystectomy for nonurological malignancy invading the bladder can lead to prolonged disease-free survival when performed with curative intent and negative margins. This procedure is crucial for complete tumor eradication in advanced cancers.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Oncology

Background:

  • Locally advanced nonurological malignancies frequently invade the bladder.
  • Partial cystectomy is sometimes necessary for complete tumor eradication.
  • The benefits of partial cystectomy in these cases are not well-established.

Purpose of the Study:

  • To evaluate the outcomes of partial cystectomy in patients with nonurological malignancies invading the bladder.
  • To identify common bladder-invading malignancies.
  • To assess complication rates and prognosis following wide en bloc resection.

Main Methods:

  • Retrospective review of 45 patients undergoing partial cystectomy for nonurological malignancy.
  • Analysis of malignancy types, invasion incidence, complication rates, and prognosis.

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  • Correlation of surgical margins and intent (curative vs. palliative) with outcomes.

    • Main Results:

    • Colorectal adenocarcinoma was the most common cause of bladder invasion.
    • Malignant invasion was present in 21.5% of bladder specimens.
    • Patients undergoing surgery with curative intent and negative margins had a 69.6% disease-free rate at mean follow-up.
    • Disease progression or cancer-related death was high in palliative cases (93.3%) and those with positive margins (94.1%).
    • Disease-specific survival was 27.3% with malignant invasion versus 41.2% with fibrous fixation only.
    • No complications were attributed to partial cystectomy.

    Conclusions:

    • Partial cystectomy is essential for managing advanced nonurological malignancies involving the bladder, whether by direct extension or fibrous reaction.
    • Achieving negative surgical margins during radical surgery with curative intent is critical for prolonged disease-free survival.
    • Wide en bloc resection ensures complete tumor excision, improving patient prognosis.