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[Clinical investigation of cefpirome for perinatal infection and infection prevention]

T Chimura1, K Murayama, T Oda

  • 1Shirataka Hospital.

The Japanese Journal of Antibiotics
|July 5, 2001
PubMed

Insights

Cefpirome (CPR) demonstrated high effectiveness and safety in treating perinatal infections, with a 98.4% efficacy rate. It also proved highly effective in preventing postoperative infections, achieving a 98.9% success rate in clinical studies.

Area of Science:

  • Infectious Diseases
  • Obstetrics and Gynecology
  • Pharmacology

Background:

  • Perinatal infections pose significant risks to mothers and newborns.
  • Postoperative infections in the perinatal period require effective prophylactic measures.

Purpose of the Study:

  • To evaluate the effectiveness and safety of cefpirome (CPR) in treating perinatal infections.
  • To assess the efficacy of CPR in preventing postoperative infections during the perinatal period.

Main Methods:

  • A study involving 62 cases of perinatal infections treated with CPR (2 g/day).
  • A study involving 88 cases for the prevention of postoperative infections during the perinatal period.
  • Adverse effects and clinical laboratory tests were monitored.

Main Results:

  • CPR achieved an effectiveness rate of 98.4% (61/62) in perinatal infections.
  • Bacterial elimination rate was 93.4% (57/61) in perinatal infections.
  • CPR showed a 98.9% (87/88) effectiveness rate in preventing postoperative infections.
  • Adverse drug eruption occurred in 0.7% (1/150) with no abnormal clinical laboratory findings.

Conclusions:

  • Cefpirome (CPR) is a highly effective and safe therapeutic option for perinatal infections.
  • CPR is also valuable for the prevention of postoperative infections in the perinatal setting.

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