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[Mixed type amyloidomas, beta2 microglobulin and AL lambda, in a long term hemodialysis patient]
E Menet1, M L Petit, F Bridoux
1Service d'anatomie et de cytologie pathologiques, Hôpital Jean Bernard, Poitiers. anapath@chu-poitiers.fr
Nephrologie
|July 5, 2001
Summary
Beta 2-microglobulin amyloidosis, a common hemodialysis complication, rarely affects soft tissues. This case details unusual gluteal tumors in a long-term hemodialysis patient, highlighting a late-stage manifestation.
Area of Science:
- Nephrology
- Pathology
- Biochemistry
Background:
- Beta 2-microglobulin amyloidosis is a known complication of long-term hemodialysis, typically affecting joints and tendons.
- Soft tissue involvement, however, is exceptionally rare.
Observation:
- A 74-year-old woman undergoing hemodialysis for 21 years presented with bilateral, symmetric gluteal tumors.
- These tumors caused significant discomfort during sitting.
Findings:
- Histological, immunohistochemical, and electron microscopy analyses confirmed the deposits were predominantly beta 2-microglobulin and lambda light chain.
- This represents an unusual localization of amyloidosis, occurring late in the course of hemodialysis therapy.
Implications:
- The findings suggest that chronic traumatism and immunoglobulin lambda light chain may promote amyloid deposition in soft tissues.
- This case expands the understanding of beta 2-microglobulin amyloidosis manifestations in hemodialysis patients.