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Related Experiment Videos

[Klobusitsky's hemocoagulase in plastic surgery].

P A Palmisano

    Minerva Chirurgica
    |June 15, 1975
    PubMed
    Summary

    Klobusitzsky haemocoagulase, a snake venom-derived hemostatic drug, effectively reduced bleeding time in patients undergoing surgery for conditions like cleft palate. This treatment showed good objective and subjective results, particularly for specific congenital anomalies.

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    Southern medical journal·1991

    Area of Science:

    • Biochemistry
    • Pharmacology
    • Surgical Research

    Context:

    • Investigating novel hemostatic agents for surgical applications.
    • Evaluating the efficacy of snake venom-derived compounds in clinical settings.
    • Addressing bleeding complications in reconstructive surgeries.

    Purpose:

    • To assess the hemostatic potential of Klobusitzsky haemocoagulase.
    • To determine the safety and effectiveness of this drug prior to various surgical procedures.
    • To quantify the reduction in bleeding time post-administration.

    Summary:

    • Klobusitzsky haemocoagulase, a drug derived from snake venom, was administered to 35 patients undergoing surgery for conditions including cleft palate and nasal septum deviation.
    • Treatment duration ranged from 2 to 6 days, with dosages and administration routes (intramuscular or intravenous) adjusted for patient age.
    • Significant reductions in bleeding time were observed across all cases, with particularly positive outcomes noted for cleft palate and nasal septum deviation surgeries.

    Impact:

    • Demonstrates the clinical utility of snake venom-derived haemocoagulase as a hemostatic agent.
    • Provides evidence for improved surgical outcomes in specific congenital anomaly corrections.
    • Highlights a potential therapeutic strategy for managing intraoperative bleeding.

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