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Antioxidant status in cerebrovascular accident
P A Kocatürk1, M C Akbostanci, C Işikay
1Departments of Pathophysiology, Faculty of Medicine, Ankara University, Sihhiye, Turkey.
Biological Trace Element Research
|July 5, 2001
Summary
Cerebrovascular accident (CVA) involves oxidative stress, indicated by altered red blood cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase activities. These changes in enzyme activity and metal concentrations suggest a link between oxidative stress and CVA progression.
Area of Science:
- Biochemistry
- Neuroscience
- Pathology
Background:
- Ischemia in cerebrovascular accident (CVA) leads to pathological changes.
- Accumulation of reactive oxygen metabolites (ROM) contributes to CVA pathology.
Purpose of the Study:
- To investigate red blood cell copper/zinc-superoxide dismutase (Cu/Zn-SOD) and catalase activities in CVA patients.
- To measure copper and zinc concentrations in plasma and red cells of CVA patients.
Main Methods:
- Spectrophotometry was used to measure Cu/Zn-SOD and catalase activities.
- Atomic absorption spectrophotometry determined copper and zinc concentrations.
- Patient cohort included 16 individuals with an average age of 64 years.
Main Results:
- Cu/Zn-SOD activity significantly increased in CVA patients, peaking around day 5.
- Catalase activity remained in the normal range on days 3 and 5, increasing by day 10.
- Elderly patients generally exhibited higher enzyme activities compared to younger controls.
- Plasma and red cell copper and zinc concentrations showed corresponding changes.
Conclusions:
- Elevated Cu/Zn-SOD activity suggests increased oxidative stress in CVA.
- Altered enzyme activities and metal concentrations in red cells and plasma reflect oxidative stress effects in CVA.