Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The glycinergic inhibitory synapse.

P Legendre1

  • 1Laboratoire de Neurobiologie des Processus adoptatifs, Université Pierre et Marie Curie, Paris, France. pascal.legendre@snv.jussieu.fr

Cellular and Molecular Life Sciences : CMLS
|July 5, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From spontaneous apple fermentations to Calvados: Insights into its aromatic complexity.

International journal of food microbiology·2025
Same author

[Acute abdominal pain in a 37-year-old woman].

La Revue de medecine interne·2024
Same author

[Weakness and weight loss in a 62 year-old patient].

La Revue de medecine interne·2022
Same author

Diversity and dynamics of bacterial and fungal communities in cider for distillation.

International journal of food microbiology·2020
Same author

The cerebrospinal fluid CD4/CD8 ratio and interleukin-6 and -10 levels in neurosarcoidosis: a multicenter, pragmatic, comparative study.

European journal of neurology·2019
Same author

Negative relationships between species richness and temporal variability are common but weak in natural systems.

Ecology·2018
Same journal

Single-Cell dissection of fibrodysplasia ossificans progressiva identifies SPP1 as a mediator of macrophage-fibroadipogenic progenitors crosstalk.

Cellular and molecular life sciences : CMLS·2026
Same journal

Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway.

Cellular and molecular life sciences : CMLS·2026
Same journal

LncRNA modulates Dpp-mediated wing development to influence flight in Aedes aegypti.

Cellular and molecular life sciences : CMLS·2026
Same journal

TROP2 promotes bone metastasis of colorectal cancer through interaction with the fibronectin-integrin axis.

Cellular and molecular life sciences : CMLS·2026
Same journal

PRMT5-Cacna1d axis maintains calcium homeostasis to regulate postnatal motor development in mice.

Cellular and molecular life sciences : CMLS·2026
Same journal

Advances and clinical potential of epigenome editing.

Cellular and molecular life sciences : CMLS·2026
See all related articles

Glycine neurotransmission is crucial for motor control and occurs beyond the spinal cord. Recent research reveals its complex roles, including excitatory functions in the developing brain and modulation by glial cells.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Neurotransmission

Background:

  • Glycine is a key inhibitory neurotransmitter in the central nervous system, particularly regulating locomotor behavior.
  • Recent research has expanded the understanding of glycine's role beyond the spinal cord and brainstem.
  • Glycinergic synapses are involved in motor control, but their functions are more diverse than previously thought.

Purpose of the Study:

  • To provide an updated overview of glycine neurotransmission based on recent research findings.
  • To highlight the expanded roles and mechanisms of glycine signaling in the brain.
  • To discuss the implications of new discoveries for understanding neurological functions and disorders.

Main Methods:

  • Review of recent scientific literature on glycine neurotransmission.

Related Experiment Videos

  • Analysis of molecular studies on glycine receptors and transporters.
  • Examination of research on the developmental and functional aspects of glycinergic synapses.

    • Main Results:

    • Glycinergic synapses are present and functional beyond the spinal cord and brainstem.
    • Glycine can act as an excitatory neurotransmitter in the immature brain.
    • Glial cells play a role in glycine modulation and release.
    • Distinct subtypes of glycine receptors with varying properties have been identified.
    • Mutations in glycine receptors are linked to human locomotor disorders like startle disease.

    Conclusions:

    • Glycine neurotransmission is more complex and widespread than previously understood.
    • New insights into glycine receptor function and distribution necessitate a revised view of inhibitory signaling.
    • Understanding glycine's multifaceted roles is critical for addressing related neurological conditions.