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Factors useful in predicting the success of oocyte donation: a 3-year retrospective analysis
N Noyes1, B S Hampton, A Berkeley
1Program for IVF, Reproductive Surgery and Infertility, Department of Obstetrics and Gynecology, New York University Medical Center, New York, New York, USA. nnoyes01@aol.com
Objective:
To establish prognostic relevance of parameters assessed in oocyte donation cycles.
Design:
Retrospective analysis.
Setting:
Large university-based donor oocyte program.
Patient(S):
All oocyte recipient cycles achieving embryo transfer from September 1995 to October 1998.
Intervention(S):
None.
Main Outcome Measure(S):
Pregnancy.
Result(S):
Recipient age and reproductive status, day 9 and 12 serum estradiol (E(2)) levels and a progesterone (P) level obtained 2 days after initiation of hormonal therapy did not correlate with pregnancy. Endometrial thickness, but not endometrial pattern, was useful in predicting pregnancy outcome. The clinical pregnancy and live-birth rate in cycles where the endometrial thickness was less than 8 mm was significantly lower when compared to cycles with an endometrial thickness > or =9 mm. Cycles where optimal quality embryos were transferred had the highest implantation (36%), clinical pregnancy (63%) and live birth (54%) rates and these rates were significantly higher than those of cycles where only poor quality embryos were available for transfer (10% implantation, 17% clinical pregnancy, and 8% live birth rates, respectively; P<.05).
Conclusion(S):
The most reliable predictive factors for pregnancy in oocyte donation cycles are the quality of the embryos transferred and the recipient's mid-cycle endometrial thickness. Recipient monitoring should minimally include ultrasound assessment of endometrial thickness.