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Updated: Aug 9, 2026

Bead Based Multiplex Assay for Analysis of Tear Cytokine Profiles
Published on: October 13, 2017
[Aqueous humor and serum interleukin-6 in patients with uveitis]
M Santos Lacomba1, C Marcos Martín, J M Gallardo Galera
1Departamento de Oftalmología, Hospital Universitario Reina Sofía de Córdoba, España. med000346@nacom.es
Purpose:
A study on local and systemic behavior of interleukin-6 in patients with active uveitis.
Methods:
IL-6 levels were measured in aqueous humor and peripheral blood samples using an enzyme-linked immunosorbent assay (ELISA) from 23 patients with uveitis and 16 control patients who had been operated for uncomplicated cataracts.
Results:
Aqueous humor of patients with uveitis showed higher levels of interleukin-6 than those of controls (p<0.001). A comparison of cytokine levels between aqueous humor and serum from patients with uveitis showed significantly higher levels of interleukin-6 in aqueous than serum (p<0.001). Correlation studies using regression test for successive steps failed to demonstrate any association between interleukin-6 levels and the different clinical characteristics of uveitis patients (laterality, onset, patterns, visual damage, localization, inflammatory activity, etiology, and association with the B27 + histocompatibility antigen).
Conclusions:
IL-6 is a cytokine that actively participates in the pathogenesis of clinical uveitis. Our data emphasize the greater local than systemic participation of this cytokine.
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