Related Experiment Video

Updated: Oct 5, 2026

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease
12:47

Spectral Karyotyping to Study Chromosome Abnormalities in Humans and Mice with Polycystic Kidney Disease

Published on: February 3, 2012

Complete karyotype discrepancy between placental and fetal cells in a case of ring chromosome 18

W Fischer1, A Dermitzel, R Osmers

  • 1Labor für Humangenetik und Pränatale Diagnostik, Dr Pruggmayer, Hermann-Ehlers-Strasse 9, D-31224 Peine, Germany. FischerW@HumGenpeine.de

Prenatal Diagnosis
|July 5, 2001
PubMed

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Nondisjunction

During meiosis, chromosomes occasionally separate improperly. This occurs due to failure of homologous chromosome separation during meiosis I or failed sister chromatid separation during meiosis II. In some species, notably plants, nondisjunction can result in an organism with an entire additional set of chromosomes, which is called polyploidy. In humans, nondisjunction can occur during male or female gametogenesis and the resulting gametes possess one too many or one too few chromosomes.When...
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