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Updated: Aug 8, 2026
09:31
Heterokaryon Technique for Analysis of Cell Type-specific Localization
Published on: March 11, 2011
Structure and chromosomal localization of chicken CD5
R Koskinen1, J Salomonsen, M Goodchild
1Turku Immunology Centre and Department of Medical Microbiology, Turku University, Turku, Finland.
Scandinavian Journal of Immunology
|July 6, 2001
Summary
Researchers isolated and mapped the chicken CD5 gene, revealing its compact structure and conserved exon arrangement. This study provides the first description of a CD5 gene
Area of Science:
- Immunogenetics
- Comparative Genomics
Background:
- CD5 is a transmembrane glycoprotein found on T cells and a subset of B cells.
- Previous studies indicated structural conservation of the CD5 protein across species.
Purpose of the Study:
- To isolate and determine the chromosomal location of the chicken CD5 gene.
- To analyze the genomic organization and structural features of the chicken CD5 gene.
Main Methods:
- Gene isolation and sequencing.
- Fluorescence in situ hybridization (FISH) for chromosomal mapping.
Main Results:
- The chicken CD5 gene is compact, spanning 3.4 kb with high GC content.
- It consists of 10 exons, with individual exons encoding scavenger receptor cysteine-rich (SRCR) domains and a proline-rich hinge region.
- The gene was mapped to chromosome five using FISH.
Conclusions:
- This is the first report detailing the genomic organization of the CD5 gene in a nonmammalian species.
- The findings support the conserved structure of the CD5 gene and its exon-intron organization across vertebrates.
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