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Risk factors for intrahospital infection in newborns
C A Tapia-Rombo1, R G Ugarte-Torres, E Alvarez-Vázquez
1Servicio de Neonatología, Hospital General Dr. Gaudencio González Garza, Centro Médico Nacional La Raza, Mexico City, Mexico. tapiachar@yahoo.com.mx
Archives of Medical Research
|July 7, 2001
Summary
Intrahospital infections (IHIs) in newborns are linked to prematurity and prolonged hospital stays. Avoiding factors like central venous catheter insertion and intubation can reduce these serious infections in neonates.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Public Health
Background:
- Intrahospital infections (IHIs) pose a significant morbidity and mortality risk in newborns due to aggressive microorganisms.
- Identifying and comparing risk factors for localized or systemic IHIs is crucial for improving neonatal outcomes.
Purpose of the Study:
- To compare risk factors associated with intrahospital infections (IHIs) in newborns.
- To differentiate risk factors between neonates with and without IHIs.
Main Methods:
- Retrospective study analyzing patient records from January 1995 to December 1998.
- Involved two groups: 73 neonates with IHIs (Group A) and 105 without (Group B).
- Utilized descriptive and inferential statistics, including Odds Ratio (OR) and multiple logistic regression for risk factor analysis (p <0.05).
Main Results:
- Lower average gestational age (35.4 weeks) in neonates with IHIs compared to controls (37.4 weeks) (p = 0.001).
- Significant risk factors identified include low birth weight, prematurity (≤30 weeks gestation), and prolonged intrahospital stay.
- Multivariate analysis highlighted vein dissection for central venous catheter insertion, orotracheal intubation, and prolonged stay (≥12 days) as key risk factors for IHIs.
Conclusions:
- Known and emerging risk factors for neonatal IHIs must be minimized.
- Particular attention should be paid to the premature newborn population, where risks are elevated.
- Preventive strategies targeting identified risk factors are essential for reducing IHI incidence in neonates.