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Vitamin D deficiency and risk of hip fractures among disabled elderly stroke patients
1Department of Neurology, Kurume University Medical Center, Japan. noukenrs@cc.hirosaki-u.ac.jp
Background And Purpose:
Risk of hip fracture after stroke is 2 to 4 times that in a reference population. Osteomalacia is present in some patients with hip fractures in the absence of stroke, while disabled elderly stroke patients occasionally have severe deficiency in serum concentrations of 25-hydroxyvitamin D (25-OHD) (
Methods:
We compared baseline serum indices of bone metabolism, bone mineral density, and hip fracture occurrence in stroke patients with serum 25-OHD /=51 nmol/L (>/=21 ng/mL; sufficient group, n=72).
Results:
Over a 2-year follow-up interval, hip fractures on the paretic side occurred in 7 patients in the deficient group and 1 patient in the insufficient group (P<0.05; hazard ratio=6.5), while no hip fractures occurred in the sufficient group. The 7 hip fracture patients in the deficient group had an osteomalacic 25-OHD level of <5 ng/mL. Higher age and severe immobilization were noted in the deficient group. Serum 25-OHD levels correlated positively with age, Barthel Index, and serum parathyroid hormone.
Conclusions:
Elderly disabled stroke patients with serum 25-OHD concentrations
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