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Related Experiment Videos

Binswanger's disease is not a single entity.

C Loeb1

  • 1Department of Neurosciences and Vision, University of Genoa, Via de Toni 5, I-16132 Genoa, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|July 10, 2001
PubMed
Summary

Binswanger's disease is not a distinct entity but a syndrome, chronic microvascular leukoencephalopathy syndrome (CMLS). This syndrome, characterized by specific cerebrovascular changes, can manifest in various hereditary and acquired conditions, including vascular dementia.

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Area of Science:

  • Neurology
  • Pathology
  • Neuroimaging

Background:

  • Binswanger's disease and subcortical arteriosclerotic encephalopathy (SAE) lack distinct clinicopathological criteria.
  • Neuroimaging reveals non-specific white matter changes, common in elderly individuals and various diseases.
  • SAE pathological features overlap with conditions like CADASIL and antiphospholipid antibody syndrome.

Purpose of the Study:

  • To clarify the clinicopathological definition of Binswanger's disease and SAE.
  • To propose a more accurate nomenclature for the observed pathological and clinical features.
  • To differentiate the syndrome from specific disease entities.

Main Methods:

  • Review of clinicopathological findings associated with Binswanger's disease and SAE.

Related Experiment Videos

  • Analysis of neuroimaging characteristics of white matter changes.
  • Comparison of pathological features across different neurological conditions.

    • Main Results:

    • Clinicopathological findings for Binswanger's disease are insufficient for a distinct entity.
    • White matter changes in neuroimaging are non-specific.
    • The pathological picture described by Olszewski is better termed chronic microvascular leukoencephalopathy (CML).

    Conclusions:

    • The clinicopathological features of Binswanger's disease represent a syndrome, CML syndrome (CMLS), not a separate disease.
    • CMLS can occur in various hereditary and acquired conditions.
    • CMLS associated with dementia is a subtype of vascular dementia.