Immunofluorescence in oral lichen planus and oral lichenoid reaction. A review

Oral lichen is a mucocutaneous disorder, which presents a confusing array of patterns and forms. Despite the reported differences between the classical lichen planus and lichenoid reaction, several reports have concurred with this lack of distinguishing features. As of yet there is no specific test for lichenoid reaction, although resolution and recurrence of lichenoid reaction on withdrawal and exposure to the drug is probably diagnostic. Thus when the clinical and histopathologic evaluation cannot confirm the diagnosis satisfactorily, the use of immunofluorescent examination is of great importance. Early diagnoses of these conditions are more likely with adjunctive use of immunofluorescent examination. Further, this tool may provide an insight into the pathogenesis of these disorders.